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With ZIMHI, You Can Be Ready
ZIMHI device with text saying "Be prepared with ZIMHI" encircling it

An opioid overdose emergency can happen at any time

WITH ZIMHI, YOU
CAN BE READY

An opioid overdose emergency can happen at
any time

WITH ZIMHI, YOU
CAN BE READY

An opioid overdose emergency can happen at any time

WITH ZIMHI, YOU
CAN BE READY

ANYONE TAKING OPIOIDS (OPIATES) COULD BE AT RISK FOR AN OPIOID OVERDOSE EMERGENCY1

The rates of an accidental opioid overdose increase every year

>4x

increase since 2019 in fake
pills that contain the illegal
drug fentanyl2

4

OF
EVERY

10

of these fake pills contain a
potentially lethal dose2

≈87%

of all overdose deaths were
accidental in 20183
If an opioid overdose emergency happens, having naloxone (na-lox-own) is essential.
Naloxone is a medicine that has been proven to reverse an opioid overdose.4

ANYONE TAKING OPIOIDS (OPIATES) COULD BE AT RISK FOR AN OPIOID OVERDOSE EMERGENCY1

The rates of an accidental opioid overdose increase every year

>4x

increase since 2019 in fake
pills that contain the illegal
drug fentanyl2

4

OF
EVERY

10

of these fake pills contain a
potentially lethal dose2

≈87%

of all overdose deaths were
accidental in 20183

If an opioid overdose emergency happens, having naloxone (na-lox-own) is essential. Naloxone is a medicine that has been proven to reverse an opioid overdose.4

WHEN SOMEONE IS EXPERIENCING AN OPIOID OVERDOSE EMERGENCY,

EVERY MOMENT MATTERS.

WHY ZIMHI?

4 SIMPLE STEPS TO USE ZIMHI

SAVE ON YOUR PRESCRIPTION

In an opioid overdose emergency,

ZIMHI MAY MAKE ALL
THE DIFFERENCE

SAVE ON YOUR PRESCRIPTION

In an opioid overdose emergency,

ZIMHI MAY
MAKE ALL THE
DIFFERENCE

SAVE ON YOUR PRESCRIPTION

In an opioid overdose emergency,

ZIMHI MAY
MAKE ALL THE
DIFFERENCE

SAVE ON YOUR PRESCRIPTION

References: 1. Opioid overdose. World Health Organization. Updated August 2021. Accessed November 30, 2021. http://www.who.int/substance_abuse/information-sheet/en 2. Department of Justice announces DEA seizures of historic amounts of deadly fentanyl-laced fake pills in public safety surge to protect U.S. communities. Department of Justice. Published September 30, 2021. Accessed December 22, 2021. justice.gov/opa/pr/department-justice-announces-dea-seizures-historic-amounts-deadly-fentanyl-laced-fake-pills 3. Hedegaard H, Miniño AM, Warner M. Drug overdose deaths in the United States, 1999-2018. NCHS Data Brief, No. 356. Hyattsville, MD: National Center for Health Statistics; 2020. 4. Reverse overdose to prevent death. Centers for Disease Control and Prevention. Accessed November 30, 2021. Updated November 17, 2021. https://www.cdc.gov/drugoverdose/prevention/reverse-od.html

INDICATION

ZIMHI is a prescription medicine used in adults and children for the treatment of an opioid emergency, such as an overdose or a possible overdose with signs of breathing problems and severe sleepiness or not being able to respond. ZIMHI is to be given right away by a caregiver and does not take the place of emergency medical care. Get emergency medical help right away after the first dose of ZIMHI, even if the person wakes up.

IMPORTANT SAFETY INFORMATION

Do not use ZIMHI if you are allergic to naloxone hydrochloride or any of the ingredients in ZIMHI.

ZIMHI is used to temporarily reverse the effects of opioid medicines. The medicine in ZIMHI has no effect in people who are not taking opioid medicines.

Use ZIMHI right away if you or your caregiver think signs or symptoms of an opioid emergency are present, even if you are not sure, because an opioid emergency can cause severe injury or death.

Family members, caregivers, or other people who may have to use ZIMHI in an opioid emergency should know where ZIMHI is stored and how to give ZIMHI before an opioid emergency happens.

Get emergency medical help right away after using the first dose of ZIMHI. Rescue breathing or CPR may be given while waiting for emergency medical help.

The signs and symptoms of an opioid emergency can return within several minutes after ZIMHI is given. If this happens, give additional injections using a new ZIMHI prefilled syringe every 2 to 3 minutes and continue to closely watch the person until emergency help is received.

ZIMHI may cause serious side effects, including sudden opioid withdrawal symptoms, which may include: body aches, fever, sweating, runny nose, sneezing, goose bumps, yawning, weakness, shivering or trembling, nervousness, restlessness or irritability, diarrhea, nausea or vomiting, stomach cramping, increased blood pressure, or increased heart rate.

Other common side effects of ZIMHI include dizziness and injection site redness.

In infants under 4 weeks old who have been receiving opioids regularly, sudden opioid withdrawal may be life-threatening if not treated the right way. Signs and symptoms include: seizures, crying more than usual, and increased reflexes.

These are not all of the possible side effects of ZIMHI. Call your doctor for medical advice about side effects.

To report SUSPECTED ADVERSE REACTIONS, contact Adamis Pharmaceuticals Corporation at 1-800-230-3935 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

IMPORTANT SAFETY INFORMATION and INDICATION for ZIMHI™

As the duration of action of naloxone hydrochloride is shorter than many opioids, keep the patient under continued surveillance and administer repeated doses of naloxone using a new ZIMHI device, as necessary, while awaiting emergency medical assistance.

Reversal of respiratory depression caused by partial agonists or mixed agonists/antagonists, such as buprenorphine and pentazocine may be incomplete. Repeat doses of ZIMHI may be required.

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IMPORTANT SAFETY INFORMATION and INDICATION for ZIMHI™

As the duration of action of naloxone hydrochloride is shorter than many opioids, keep the patient under continued surveillance and administer repeated doses of naloxone using a new ZIMHI device, as necessary, while awaiting emergency medical assistance.

More
+