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PATIENTS & CAREGIVERS / ABOUT ZIMHI

In an opioid overdose emergency rescue situation,

ZIMHI MAY MAKE ALL
THE DIFFERENCE

ZIMHI is a shot you can give to a person having an opioid (opiate) overdose emergency. It helps reverse the effect of opioids so the person can breathe normally again.1

A ZIMHI shot is given in the outside of the upper thigh. Each ZIMHI device is filled with a 5-mg dose of naloxone (na-lox-own).1 Naloxone is a medicine that has been proven to reverse an opioid overdose.2

In an opioid overdose emergency rescue situation,

ZIMHI MAY MAKE ALL THE DIFFERENCE

ZIMHI is a shot you can give to a person having an opioid (opiate) overdose emergency. It helps reverse the effect of opioids so the person can breathe normally again.1

A ZIMHI shot is given in the outside of the upper thigh. Each ZIMHI device is filled with a 5-mg dose of naloxone (na-lox-own).1 Naloxone is a medicine that has been proven to reverse an opioid overdose.2

ZIMHI device

ZIMHI IS DIFFERENT FROM OTHER NALOXONE MEDICINES.

PROVIDED AS AN EASY-TO-USE
PREFILLED INJECTION1,3,4

HIGHER DOSE GETS INTO
THE BLOOD FAST1,3,4

STAYS IN THE BLOOD LONGER
THAN A 2-mg IM DOSE1

Note: This is information about how the medicine moves throughout the body. It is unknown how this affects how well
the drug works. It does not account for differences from person to person.

ZIMHI IS DIFFERENT
FROM OTHER
NALOXONE MEDICINES.

PROVIDED AS AN EASY-TO-USE
PREFILLED INJECTION1,3,4

HIGHER DOSE GETS INTO
THE BLOOD FAST1,3,4

STAYS IN THE BLOOD LONGER
THAN A 2-mg IM DOSE1

Note: This is information about how the medicine moves throughout the body. It is unknown how this affects how well the drug works. It does not account for differences from person to person.

WHY IS A HIGH DOSE AND INJECTABLE NALOXONE IMPORTANT?

During an opioid overdose emergency, there are a lot of things that make it hard to know how much naloxone will be needed. For example, caregivers often don’t know how much of the opioid was taken or how the person’s body will respond.5
As an injectable device, ZIMHI can help you get more naloxone into the blood when every minute matters. Also, its 5-mg dose provides more naloxone when it’s hard to know how much the person will need.

ZIMHI IS NOT A SUBSTITUTE FOR EMERGENCY MEDICAL CARE.

ALWAYS CALL 9-1-1

during a suspected opioid overdose emergency.1

WHY IS A HIGH DOSE AND INJECTABLE NALOXONE IMPORTANT?

During an opioid overdose emergency, there are a lot of things that make it hard to know how much naloxone will be needed. For example, caregivers often don’t know how much of the opioid was taken or how the person’s body will respond.5

As an injectable device, ZIMHI can help you get more naloxone into the blood when every minute matters. Also, its 5-mg dose provides more naloxone when it’s hard to know how much the person will need.

ZIMHI IS NOT A SUBSTITUTE FOR EMERGENCY MEDICAL CARE.

ALWAYS CALL 9-1-1

during a suspected opioid overdose emergency.1

When pulling them out of an opioid overdose

EVERY MOMENT MATTERS

Actor portrayal

4 SIMPLE STEPS TO USE ZIMHI

IS IT AN OVERDOSE?

SAVE ON YOUR PRESCRIPTION

When pulling them out
of an opioid overdose

EVERY
MOMENT
MATTERS

Actor portrayal

4 SIMPLE STEPS TO USE ZIMHI

IS IT AN OVERDOSE?

SAVE ON YOUR PRESCRIPTION

When pulling them out
of an opioid overdose

EVERY
MOMENT
MATTERS

Actor portrayal

4 SIMPLE STEPS TO USE ZIMHI

IS IT AN OVERDOSE?

SAVE ON YOUR PRESCRIPTION

In an opioid overdose emergency,

ZIMHI MAY MAKE ALL
THE DIFFERENCE

SAVE ON YOUR PRESCRIPTION

In an opioid overdose emergency,

ZIMHI MAY
MAKE ALL THE
DIFFERENCE

SAVE ON YOUR PRESCRIPTION

In an opioid overdose emergency,

ZIMHI MAY
MAKE ALL THE
DIFFERENCE

SAVE ON YOUR PRESCRIPTION

References: 1. ZIMHI. Prescribing information. Adamis Pharmaceuticals Corporation; 2021. 2. Reverse overdose to prevent death. Centers for Disease Control and Prevention. Updated November 17, 2021. Accessed November 30, 2021. https://www.cdc.gov/drugoverdose/prevention/reverse-od.html 3. Kloxxado. Prescribing Information. Hikma Pharmaceuticals USA Inc.; April 2021. 4. Narcan. Prescribing Information. Adapt Pharma Operations Limited; Rev 08/2020. 5. FDA Advisory Committee on the most appropriate dose or doses of naloxone to reverse the effects of life-threatening opioid overdose in the community settings. Adapt Pharma Operations Limited; 2016.

INDICATION

ZIMHI is a prescription medicine used in adults and children for the treatment of an opioid emergency, such as an overdose or a possible overdose with signs of breathing problems and severe sleepiness or not being able to respond. ZIMHI is to be given right away by a caregiver and does not take the place of emergency medical care. Get emergency medical help right away after the first dose of ZIMHI, even if the person wakes up.

IMPORTANT SAFETY INFORMATION

Do not use ZIMHI if you are allergic to naloxone hydrochloride or any of the ingredients in ZIMHI.

ZIMHI is used to temporarily reverse the effects of opioid medicines. The medicine in ZIMHI has no effect in people who are not taking opioid medicines.

Use ZIMHI right away if you or your caregiver think signs or symptoms of an opioid emergency are present, even if you are not sure, because an opioid emergency can cause severe injury or death.

Family members, caregivers, or other people who may have to use ZIMHI in an opioid emergency should know where ZIMHI is stored and how to give ZIMHI before an opioid emergency happens.

Get emergency medical help right away after using the first dose of ZIMHI. Rescue breathing or CPR may be given while waiting for emergency medical help.

The signs and symptoms of an opioid emergency can return within several minutes after ZIMHI is given. If this happens, give additional injections using a new ZIMHI prefilled syringe every 2 to 3 minutes and continue to closely watch the person until emergency help is received.

ZIMHI may cause serious side effects, including sudden opioid withdrawal symptoms, which may include: body aches, fever, sweating, runny nose, sneezing, goose bumps, yawning, weakness, shivering or trembling, nervousness, restlessness or irritability, diarrhea, nausea or vomiting, stomach cramping, increased blood pressure, or increased heart rate.

Other common side effects of ZIMHI include dizziness and injection site redness.

In infants under 4 weeks old who have been receiving opioids regularly, sudden opioid withdrawal may be life-threatening if not treated the right way. Signs and symptoms include: seizures, crying more than usual, and increased reflexes.

These are not all of the possible side effects of ZIMHI. Call your doctor for medical advice about side effects.

To report SUSPECTED ADVERSE REACTIONS, contact Adamis Pharmaceuticals Corporation at 1-800-230-3935 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

IMPORTANT SAFETY INFORMATION and INDICATION for ZIMHI™

As the duration of action of naloxone hydrochloride is shorter than many opioids, keep the patient under continued surveillance and administer repeated doses of naloxone using a new ZIMHI device, as necessary, while awaiting emergency medical assistance.

Reversal of respiratory depression caused by partial agonists or mixed agonists/antagonists, such as buprenorphine and pentazocine may be incomplete. Repeat doses of ZIMHI may be required.

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IMPORTANT SAFETY INFORMATION and INDICATION for ZIMHI™

As the duration of action of naloxone hydrochloride is shorter than many opioids, keep the patient under continued surveillance and administer repeated doses of naloxone using a new ZIMHI device, as necessary, while awaiting emergency medical assistance.

More
+