One 5-mg intramuscular dose provides a higher plasma concentration and
exposure compared with a 2-mg intramuscular dose¹

Mean plasma concentration of naloxone over 30 minutes

Mean plasma concentration of
naloxone over 30 minutes

Note: The clinical relevance of these pharmacokinetic data is unknown. These data do not account for interpatient variability.
C_max=maximum concentration; IM=intramuscular.

References: 1. ZIMHI. Prescribing information. 2. Spinal Cord. How long can the brain go without oxygen? What happens? Accessed October 28, 2020. https://www.spinalcord.com/blog/what-happens-to-the-brain-after-a-lack-of-oxygen 3. Family Caregiver Alliance. Hypoxic-anoxic brain injury. Updated 2004. Accessed October 28, 2020. https://www.caregiver.org/hypoxic-anoxic-brain-injury 4. Medline Plus. CPR—adult and child after onset of puberty. Updated October 8, 2020. Accessed October 28, 2020. https://medlineplus.gov/ency/article/000013.htm 5. Mell HK, Mumma SN, Hiestand B, Carr BG, Holland T, Stopyra J. Emergency medical services response times in rural, suburban, and urban areas. JAMA Surg. 2017;152(10):983. doi:10.1001/jamasurg.2017.2230 6. Centers for Disease Control and Prevention. Calculating total daily dose of opioids for safer dosage. Accessed October 28, 2020. https://www.cdc.gov/drugoverdose/pdf/calculating_total_daily_dose-a.pdf

INDICATION

ZIMHI is an opioid antagonist indicated for the emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or central nervous system depression in adult and pediatric patients. ZIMHI is intended for immediate administration as emergency therapy in settings where opioids may be present. ZIMHI is not a substitute for emergency medical care.

IMPORTANT SAFETY INFORMATION

As the duration of action of naloxone hydrochloride is shorter than many opioids, keep the patient under continued surveillance and administer repeated doses of naloxone using a new ZIMHI device, as necessary, while awaiting emergency medical assistance.

Reversal of respiratory depression caused by partial agonists or mixed agonists/antagonists, such as buprenorphine and pentazocine may be incomplete. Repeat doses of ZIMHI may be required.

Use in patients who are opioid dependent may precipitate opioid withdrawal. In neonates, opioid withdrawal may be life-threatening if not recognized and properly treated. Monitor for the development of signs and symptoms of opioid withdrawal.

Abrupt postoperative reversal of opioid depression may result in adverse cardiovascular (CV) effects. These events have primarily occurred in patients who had pre-existing CV disorders or received other drugs that may have similar adverse CV effects. Monitor these patients closely in an appropriate healthcare setting after use of naloxone hydrochloride.

After use, the ZIMHI needle is exposed until the safety guard is deployed. A needlestick injury could occur during use in emergency situations. In the event of accidental needlestick injury, medical attention should be sought.

The following adverse reactions were most commonly observed in ZIMHI clinical studies: dizziness, lightheadedness, and elevated bilirubin.

To report SUSPECTED ADVERSE REACTIONS, call 1-800-230-3935 or FDA at
1-800-FDA-1088 or www.fda.gov/medwatch